NEW YORK 鈥 Tim Friede has been bitten by snakes hundreds of times 鈥 often on purpose. Now scientists are studying his blood in hopes of creating a better treatment for snake bites.
Friede has long had a fascination with reptiles and other venomous creatures. He used to milk scorpions' and spiders' venom as a hobby and kept dozens of snakes at his Wisconsin home.
Hoping to protect himself from snake bites 鈥 and out of what he calls "simple curiosity" 鈥 he began injecting himself with small doses of snake venom and then slowly increased the amount to try to build up tolerance. He would then let snakes bite him.
"At first, it was very scary," Friede said. "But the more you do it, the better you get at it, the more calm you become with it."

This undated photo provided by Centivax in 2025 shows Tim Friede, who is hyper-immune to the venom of various snakes, with a water cobra wrapped around his arm
While no doctor or emergency medical technician 鈥 or anyone, really 鈥 would ever suggest this is a remotely good idea, experts say his method tracks how the body works. When the immune system is exposed to the toxins in snake venom, it develops antibodies that can neutralize the poison. If it's a small amount of venom the body can react before it's overwhelmed. And if it's venom the body has seen before, it can react more quickly and handle larger exposures.
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Friede has withstood snakebites and injections for nearly two decades and still has a refrigerator full of venom. In videos posted to his YouTube channel, he shows off swollen fang marks on his arms from black mamba, taipan and water cobra bites.
"I wanted to push the limits as close to death as possible to where I'm just basically teetering right there and then back off of it," he said.
But Friede also wanted to help. He emailed every scientist he could find, asking them to study the tolerance he'd built up.
And there is a need: Around 110,000 people die from snakebite every year, according to the World Health Organization. And making antivenom is expensive and difficult. It is often created by injecting large mammals like horses with venom and collecting the antibodies they produce. These antivenoms are usually only effective against specific snake species, and can sometimes produce bad reactions due to their nonhuman origins.
When Columbia University's Peter Kwong heard of Friede, he said, "Oh, wow, this is very unusual. We had a very special individual with amazing antibodies that he created over 18 years."

In this photo provided by Centivax, Tim Friede, center, stands in a lab in South San Francisco, Calif., in 2023, that is using his blood to prepare an antivenom to the bites of various snakes.
In a study published Friday in the journal Cell, Kwong and collaborators shared what they were able to do with Friede's unique blood: They identified two antibodies that neutralize venom from many different snake species with the aim of someday producing a treatment that could offer broad protection.
It's very early research 鈥 the antivenom was only tested in mice, and researchers are still years away from human trials. And while their experimental treatment shows promise against the group of snakes that include mambas and cobras, it's not effective against vipers, which include snakes like rattlers.
"Despite the promise, there is much work to do," said Nicholas Casewell, a snakebite researcher at Liverpool School of Tropical Medicine in an email. Casewell was not involved with the new study.

This photo provided by Centivax shows Mark Bellin and Hannah Hirou who are involved in efforts to produce an antivenom to counteract the bites of various snakes, at a lab in South San Francisco, Calif., in 2025.
Friede's journey has not been without its missteps. Among them: He said after one bad snake bite he had to cut off part of his finger. And some particularly nasty cobra bites sent him to the hospital.
Friede is now employed by Centivax, a company trying to develop the treatment and that helped pay for the study. He's excited that his 18-year odyssey could one day save lives from snakebite, but his message to those inspired to follow in his footsteps is simple: "Don't do it," he said.
Photos: Insect and animal life around the globe

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A crow and a seagull fight for a prey in Tallinn Bay, Tallinn, Estonia, Sunday, Sept. 29, 2024. (AP Photo/Sergei Grits)

A Stag in rut bellows in early morning mist Bushy Park southwest London, Saturday, Sept. 28, 2024. (AP Photo/Alastair Grant)

Deer cross a road in the woods of the Taurus region near Frankfurt, Germany, Saturday, Sept. 28, 2024. (AP Photo/Michael Probst)

A deer walks on a road in the woods of the Taurus region near Frankfurt, Germany, Saturday, Sept. 28, 2024. (AP Photo/Michael Probst)

A raptor after killing a pigeon in a garden in Frankfurt, Germany, Saturday, Sept. 21, 2024. (AP Photo/Michael Probst)

A one horned rhinoceros and its calf graze in Pobitora wildlife sanctuary on the outskirts of Guwahati, India, Wednesday, Sept. 25, 2024. (AP Photo/Anupam Nath)

A spider waits for his prey at the center of its net covered by water droplets in the forest outside Tallinn, Estonia, Friday, Sept. 20, 2024. (AP Photo/Sergei Grits)

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A visitor looks at male Hippo Tony, at the Khao Kheow Open Zoo in Chonburi province, Thailand, Thursday, Sept. 19, 2024. (AP Photo/Sakchai Lalit)

A fawn and its mother stand together in a forest of the Taunus region in Frankfurt, Germany, Tuesday, Sept. 17, 2024. (AP Photo/Michael Probst)

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A fourteen-pointer rests in the forest as rutting time begins in the Taunus region in Frankfurt, Germany, Tuesday, Sept. 17, 2024. (AP Photo/Michael Probst)

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Butterflies feed on flowers nectar in a forest outside Tallinn, Estonia, Tuesday, Sept. 3, 2024. (AP Photo/Sergei Grits)

A bee and a sunflower are silhouetted against the setting sun in a field Saturday, Sept. 7, 2024, near Lawrence, Kan. The field, planted annually by the Grinter family, draws thousands of visitors during the weeklong late summer blossoming of the flowers. (AP Photo/Charlie Riedel)

Panda Yuanyuan eats her birthday cake for her 20 years old at the Taipei Zoo in Taipei, Taiwan, Friday, Aug. 30, 2024. Yuanyuan was a gift from China to mark warming ties with Taiwan in 2008. (AP Photo/Chiang Ying-ying)

A sea lion is covered in sand on San Carlos beach in Monterey, Calif., Friday, Aug. 23, 2024. (AP Photo/Nic Coury)

A bee flies to a sunflower on a field in the outskirts of Frankfurt, Germany, Wednesday, Aug. 28, 2024. (AP Photo/Michael Probst)

Flamingos in their enclosure at the Tierpark zoo in Berlin, Germany, Thursday, Aug. 22, 2024. (AP Photo/Markus Schreiber)

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Emily, a new born Rothschild's Giraffe, born on Aug. 11, 2024. stands in front of her mother Katharina, during a name giving event at the Tierpark zoo in Berlin, Germany, Thursday, Aug. 22, 2024. (AP Photo/Markus Schreiber)

Two storks stand in their nest in Wehrheim near Frankfurt, Germany, Tuesday, Oct. 1, 2024. (AP Photo/Michael Probst)

Two storks stand in their nest in Wehrheim near Frankfurt, Germany, Tuesday, Oct. 1, 2024. (AP Photo/Michael Probst)

A flock of birds fly past turbines at a wind farm, Sunday, Sept. 29, 2024, near Spearville, Kan. (AP Photo/Charlie Riedel)

Icelandic horses play at a stud farm in Wehrheim near Frankfurt, Germany, Monday, Sept. 30, 2024. (AP Photo/Michael Probst)

A raptor after killing a pigeon in a garden in Frankfurt, Germany, Saturday, Sept. 21, 2024. (AP Photo/Michael Probst)

A spider waits for his prey at the center of its net covered by water droplets in the forest outside Tallinn, Estonia, Friday, Sept. 20, 2024. (AP Photo/Sergei Grits)

Giraffes roam their enclosure at the Living Desert Zoo and Gardens in Palm Desert, Calif., Thursday, Sept. 19, 2024. (AP Photo/Jae C. Hong)

A visitor looks at male Hippo Tony, at the Khao Kheow Open Zoo in Chonburi province, Thailand, Thursday, Sept. 19, 2024. (AP Photo/Sakchai Lalit)

A lion cub, born on July 31, and mother "Indi" play in an area visible to zoo visitors for the first time, at Schwerin zoo, in Schwerin, Germany, Wednesday, Sept. 18, 2024. (Jens B眉ttner/dpa via AP)

Two-month-old baby hippo Moo Deng and her mother Jona are seen at the Khao Kheow Open Zoo in Chonburi province, Thailand, Thursday, Sept. 19, 2024. (AP Photo/Sakchai Lalit)

Geese stand on an outdoor table in a flooded neighbourhood in Ostrava, Czech Republic, Tuesday, Sept. 17, 2024. (AP Photo/Darko Bandic)

A fawn and its mother stand together in a forest of the Taunus region in Frankfurt, Germany, Tuesday, Sept. 17, 2024. (AP Photo/Michael Probst)

A swan family watches Sunday walkers at Lake Baldeney in Essen, Germany, Sunday, Sept. 15, 2024. (AP Photo/Martin Meissner)

A fourteen-pointer rests in the forest as rutting time begins in the Taunus region in Frankfurt, Germany, Tuesday, Sept. 17, 2024. (AP Photo/Michael Probst)

Seagulls fly over Al Arish beach, 50 km (32,5 miles), West of Rafah border crossing between Egypt and the Gaza Strip in Al Arish, Egypt, Monday, Sept. 9, 2024. (AP Photo/Amr Nabil)

A beetle basks in the sun on a city meadow in Tallinn, Estonia, Monday, Sept. 9, 2024. (AP Photo/Sergei Grits)

A bee and a sunflower are silhouetted against the setting sun in a field Saturday, Sept. 7, 2024, near Lawrence, Kan. The field, planted annually by the Grinter family, draws thousands of visitors during the weeklong late summer blossoming of the flowers. (AP Photo/Charlie Riedel)

A stork stands in the nest in Wehrheim, near Frankfurt, Germany, Monday, Sept. 9, 2024. (AP Photo/Michael Probst)

Butterflies feed on flowers nectar in a forest outside Tallinn, Estonia, Tuesday, Sept. 3, 2024. (AP Photo/Sergei Grits)

A bee flies to a sunflower on a field in the outskirts of Frankfurt, Germany, Wednesday, Aug. 28, 2024. (AP Photo/Michael Probst)

Panda Yuanyuan eats her birthday cake for her 20 years old at the Taipei Zoo in Taipei, Taiwan, Friday, Aug. 30, 2024. Yuanyuan was a gift from China to mark warming ties with Taiwan in 2008. (AP Photo/Chiang Ying-ying)

A sea lion is covered in sand on San Carlos beach in Monterey, Calif., Friday, Aug. 23, 2024. (AP Photo/Nic Coury)

Flamingos in their enclosure at the Tierpark zoo in Berlin, Germany, Thursday, Aug. 22, 2024. (AP Photo/Markus Schreiber)

Emily, a new born Rothschild's Giraffe, born on Aug. 11, 2024. stands in front of her mother Katharina, during a name giving event at the Tierpark zoo in Berlin, Germany, Thursday, Aug. 22, 2024. (AP Photo/Markus Schreiber)